The Department was established in 1956, it was shitted at the Allama I.I Kazi Campus, Jamshoro in 1961 and to its present premises in 1965. Two of its new laboratories were constructed in 1993 and were named after the former Chairman, Late Prof. S. Ishfaque Hussain Shah who died to heart failure on August 27, 1991.

Since its inception, the department had been imparting instructions for the 3-year B.Sc. (Hons.) courses and one/ two year M.Sc. Degree programs. 4-year BS Program has been introduced since 2003. It has been disseminating specialized knowledge in the fice fields of Entomology, Parasitology, Vertebrate Biology, Endocrinology and Genetics. The Department Also offers programs leading to P.Phil and Ph.D Degrees in these specialized fields. It has produced 16 Ph.Ds. and 40 M.Phils. since its inception. Present enrolment in the department is 700 including M.Phil / Ph.D students.

Currently two research projects are running under the Principal Investigation of Dr. Riffat Sultana funded by PSF and HEC.

The department has been progressing steadily and at present it is the second largest department in the Faculty of Natural Sciences, University of Sindh.